About This Compound

SS-31 (Elamipretide) is a tetrapeptide that selectively concentrates in the inner mitochondrial membrane, where it binds to cardiolipin — the critical phospholipid that anchors the electron transport chain complexes. By stabilizing cardiolipin, SS-31 restores mitochondrial cristae architecture, dramatically improves electron transport efficiency, and reduces reactive oxygen species (ROS) production. Research demonstrates SS-31 reverses age-related mitochondrial dysfunction, restores ATP production in aged tissues, reduces ischemia-reperfusion injury, and improves cardiac and skeletal muscle function. This is the most targeted mitochondrial rescue compound in research — operating at the exact site of energy failure.